Many stage‐specific embryonic antigens (SSEAs) have been identified as glycoconjugates. These molecules may play diverse roles in the development of the embryo, including regulation of cell growth, recognition, and differentiation. The example of SSEA‐1 is described in detail. This molecule appears to play an essential role in compaction of the early mouse embryo, and may illustrate the general importance of carbohydrate‐carbohydrate interactions in controlling cell surface interactions in development.

I defend a slightly modified version of geach's rule r, I.E., That although both a and b are g, It is possible for a to be the same f as b and a different h than b, Provided that the question whether a and b are the same g is undecidable. Answering those who object to relative identity I claim that they tacitly adhere to a false fregean view, I.E., That one cannot use a singular term to denote an entity (...) x if it is not true that for every y, X=y or not x=y. I show, However, That such terms are, And must be, Used by every empirically oriented language with finite or infinite predicative arsenal, And hence relative identity is more handy than absolute identity. Finally I give a version of leibniz's law for relative identity. (shrink)

Wittgenstein’s first account of meaning was that sentences are pictures: the meaning of a sentence is a state of affairs it portrays. States of affairs are arrangements of some basic entities, the Objects. Sentences consist of names of Objects; an arrangement of such names, i.e., a sentence, shows how the named Objects are arranged. A sentence says that the state of affairs it thus pictures exists, hence it is true or false. That theory of meaning as picturing is based on (...) a primitive relation of naming, but what it is for an item to name another the Tractatus does not say. (shrink)

It has been persuasively argued that music refers. For example, a passage that resembles the demeanour of people under the sway of emotion E is seen as itself being E and, thus, as referring to E. Yet what is the purpose of such reference? Serious music, I say, works as a proof. A passage that refers to E is cast as a well-formed formula in a calculus. That formula is then creatively developed in accordance with the rules of that calculus (...) (e.g. harmony and counterpoint in classical music). As in scientific proofs, intermediary generated formulae need not have external meaning over and above the character they have due to their role in the formal sequence. Yet finally a formula is derived that does have external meaning; for example, it refers to emotion F. The composer has thus fictionally proved that E is equal to F, e.g. that hope is futile or that love conquers all. (shrink)

According to the 'axiom of existence', Adopted in this article, Terms which do not denote existent entities do not denote at all. 'past entities', 'future entities', 'possible entities', 'fictional entities', Etc. Do not exist. The class of denoting terms has, Therefore, A changing membership. 'nixon' denotes now, But will fail to denote one hundred years from now. The same is true for terms indicating properties (e.G., '... Is a missile'). A theory of meaning and truth is developed on the basis (...) of this axiom. A denotationless term may still be meaningful. 'x' means, In english, 'the entity which ...' where the dots stand for a certain conjunction of open sentences known to speakers of english in various degrees, Found in reference books of authority, Etc. A statement can be true through either correspondence or analyticity. Thus 'nixon is the u.S. President' is (now) true in both ways. 'socrates was a philosopher', '2+2=4', And 'hamlet killed polonius' are only analytically true. 'polonius killed hamlet' is false. (shrink)

In both "individuals" and "the bounds of sense" p f strawson has argued that the no-Ownership theory of mental states is incoherent. He has argued for example, That the no-Ownership theorist must use, In stating his theory, A concept the validity of which the theory attempts to deny (i.E., That experiences are necessarily owned). I show that this argument is based on a confusion of modalities, Mistaking "de dicto" for "de re" necessity. I further show that the very claim that (...) sets of experiences are identifiable only through reference to their "havers" is mistaken. Mental events are individuated and grouped together exactly as physical events are. I therefore conclude that a person "consists" of, "inter alia", Mental particulars; his thoughts are his in the same sense that his legs are his own. Siding with hume against kant, Strawson, And shoemaker, I argue that there are criteria for ascription of experience to persons and a person must use those criteria in ascribing experiences, Even current ones, To himself. Hence, A person who misapplies those criteria may be mistaken in believing of a certain experience that it is (or is not) his own. (shrink)

Relativists try to reduce the realistic notion of truth or make do without it. Rorty, e.g., regards 'true' as an indexical, or as a commendatory term; both construals result in contradictions. Dummett replaces truth by assertability, but that results in a vicious regress, making it impossible, first, to state the theory, and second, that nonomniscients know anything. Quine, rejecting meaning and reference altogether, ends with a picture of language that is a mere pattern of (e.g., vocal) interactions; by its own (...) light, that theory is incomprehensible and unjustifiable. Truth as correspondence to reality is therefore an irreducible notion. (shrink)

Relativists try to reduce the realistic notion of truth or make do without it. Rorty, e.g., regards 'true' as an indexical, or as a commendatory term; both construals result in contradictions. Dummett replaces truth by assertability, but that results in a vicious regress, making it impossible, first, to state the theory, and second, that nonomniscients know anything. Quine, rejecting meaning and reference altogether, ends with a picture of language that is a mere pattern of (e.g., vocal) interactions; by its own (...) light, that theory is incomprehensible and unjustifiable. Truth as correspondence to reality is therefore an irreducible notion. (shrink)

Synaesthesia is a condition in which one type of stimulation evokes the sensation of another, as when the hearing of a sound produces photisms, i.e. mental percepts of colours. R is a 20 year old colour blind subject who, in addition to the relatively common grapheme-colour synaesthesia, presents a rarely reported cross modal perception in which a variety of visual stimuli elicit aura-like percepts of colour. In R, photisms seem to be closely related to the affective valence of stimuli and (...) typically bring out a consistent pattern of emotional responses. The present case study suggests that colours might be an intrinsic category of the human brain. We developed an empirical methodology that allowed us to study the subject's otherwise inaccessible phenomenological experience. First, we found that R shows a Stroop effect elicited by photisms despite the fact that he does not show a regular Stroop with real colours. Secondly, by manipulating the colour context we confirmed that colours can alter R's emotional evaluation of the stimuli. Furthermore, we demonstrated that R's auras may actually lead to a partially inverted emotional spectrum where certain stimuli bring out emotional reactions opposite to the normal ones. These findings can only be accounted for by considering R's subjective colour experience or qualia. Therefore the present paper defends the view that qualia are a useful scientific concept that can be approached and studied by experimental methods. (shrink)

How should pragmatists respond to and contribute to the resolution of one of America's greatest and most enduring problems? Given that the most important thinkers of the pragmatist movement—Charles S. Peirce, William James, John Dewey, and George Herbert Mead—said little about the problem of race, how does their distinctly American way of thinking confront the hardship and brutality that characterizes the experience of many African Americans in this country? In 12 thoughtful and provocative essays, contemporary American pragmatists connect ideas with (...) action and theory with practice to come to terms with this seemingly intractable problem. Exploring themes such as racism and social change, the value of the concept of race, the role of education in ameliorating racism, and the place of democracy in dealing with the tragedy of race, the voices gathered in this volume consider how pragmatism can focus new attention on the problem of race. Contributors are Michael Eldridge, Eddie S. Glaude, Jr., Judith M. Green, D. Micah Hester, Donald F. Koch, Bill E. Lawson, David E. McClean, Gregory F. Pappas, Scott L. Pratt, Alfred E. Prettyman, John R. Shook, Paul C. Taylor, and Cornel West. (shrink)

Acute exercise consistently benefits both emotion and cognition, particularly cognitive control. We evaluated acute endurance exercise influences on emotion, domain-general cognitive control, and the cognitive control of emotion, specifically cognitive reappraisal. Thirty-six endurance runners, defined as running at least 30 miles per week with one weekly run of at least 9 miles (21 female, age 18-30 years) participated. In a repeated measures design, participants walked at 57% age-adjusted maximum heart rate (HRmax) (range 51-63%) and ran at 70% HRmax (range 64-76%) (...) for 90 minutes on two separate days. Participants completed measures of emotional state and the Stroop test of domain-general cognitive control before, every 30 minutes during, and 30 minutes after exercise. Participants also completed a cognitive reappraisal task after exercise. Functional near-infrared spectroscopy tracked changes in oxygenated and deoxygenated hemoglobin levels in the prefrontal cortex (PFC). Endurance exercise elevated positive emotion and cognitive reappraisal success. Endurance exercise reduced Stroop response time and test-evoked PFC oxygenation during exercise. Results suggest that even at relatively moderate intensities, endurance athletes benefit emotionally from running both during and after exercise, and task-related prefrontal cortex oxygenation reductions do not appear to hinder prefrontal-dependent cognitive control. (shrink)

The same research proposal was submitted to 24 district health authority (DHA) research ethics committees in different parts of the country. The objective was to obtain permission for a multi-centre research project. The study of neonatal care in different types of unit (regional, subregional and district), required that four health authorities were approached in each of six widely separated health regions in England. Data were collected and compared concerning aspects of processing, including application forms, information required, timing and decision-making. The (...) key finding was that ethics committees received and processed the applications variably, reflecting individual factors and local problems. To improve consensus and facilitate multicentre studies, standard forms and instructions are suggested and the establishment of a national committee or advisory group advocated. (shrink)

Provability, Computability and Reflection.

Traditionally, philosophers held that expressions are meaningful which have a mental entity and sentences are true when their meaning corresponds to reality. Wittgenstein is most often read by contemporary philosophers to reject both theses: meanings cannot constrain use of language, and reference to external reality is inconceivable. Zemach is influenced by Wittgenstein as well, but demonstrates the error of a relativistic interpretation of his work, especially when Wittgenstein's later work on the philosophy of psychology is fully considered. Combining his interpretation (...) of Wittgenstein as a mentalist with the use of Substance Logic, and the idea that meanings and their referents are tokens of the same type, Zemach restores the traditional view. The Reality of Meaning presents a clear survey of the major issues in contemporary philosophy of language. A lively, good-humored philosophical argument that is informative, topical, and well seasoned with common sense, it is a book for all readers of philosophy, psychology, and cognitive science. (shrink)

In their “social contextual view” of emotional mimicry, authors Hess and Fischer (2022) put forward emotional mimicry as a social regulator, considering it a social act, bound to certain affiliative contexts or goals. In this commentary, we argue that the core function of mimicry is to ease predicting conspecifics’ behaviours and the environment, and that as a consequence, this often smoothens social interactions. Accordingly, we make three main points. First, we argue that there is no good reason to believe that (...) the mimicry of negative expressions is fundamentally different than the mimicry of positive or ambiguous or autonomic expressions. Second, we give examples of empirical evidence that mimicry is not always a social act. Third, we show that mimicry has primary benefits for the mimicker. As such, we will briefly summarise and elaborate on the relevant findings in these respects, and propose a comparative, multi-method and ecologically valid approach which can explain the multifaceted character of the phenomenon. (shrink)

We argue that on logical grounds the constructivist algorithms mentioned by Quartz & Sejnowski (Q&S) do not resolve the learning paradox. In contrast, a neural network might acquire a more powerful structure by means of phase transitions. The latter kind of developmental mechanism can be in agreement with the constructivist manifesto.

The Birkhoff-Maltsev problem asks for a characterization of those lattices each of which is isomorphic to the lattice L(K) of all subquasivarieties for some quasivariety K of algebraic systems. The current status of this problem, which is still open, is discussed. Various unsolved questions that are related to the Birkhoff-Maltsev problem are also considered, including ones that stem from the theory of propositional logics.

The relevance of the research is the intensity of noise emitted by lorries depends on the regime of the vehicle movement. One of the main negative factors caused by road vehicles is air pollution with exhaust gases. The article presents results for noise caused by lorries and gas usage while the vehicle is accelerating. The subject of the study is 4 lorries, and they also feature fuel recording systems which are less than 5 years old. Research methodology. The level of (...) noise emitted by heavyweight transport vehicles is measured according to Lithuanian standard LST ISO 1996-2:2008 requirements. During the tests the noise levels of L A,eq, L C,eq, L C,peak were measured. The tests were done 5 times each and the results are presented as arithmetical averages. Fuel consumption is registered in vehicle data registration system. The researched vehicles have to comply with environmental safety normative requirements; that the vehicle carbon monoxide, particulate matter, nitrogen oxides, unburned fuel and other hazardous substances contained in the combustion gases must not exceed the prescribed limits. The results of the experimental studies show that EURO6 lorries noise level is the lowest compared to the EURO4 and EURO5. After carrying out the analysis of the caused noise and gas usage, it was found that noise pollution and gas usage are higher without speed control system. The noise caused by lorries can be described in square polynomial which defines the noise inclination change while vehicle is accelerating. Scientific novelty of the research a complex research on noise and fuel consumption of lorries by using and not using speed control system. Research idea and problem is to achieve sustainable transport development objectives, in particular the reduction of greenhouse gas emissions under the Kyoto Protocol. It is very important to find ways to forecast and reduce transport noise pollution, while also reducing overall pollution, as well as mitigating the impact on the global climate., Conclusion – after conducting a lorry noise and fuel consumption analysis, it was determined that not using speed control system increases the noise and fuel consumption and if the system is used both of these factors decrease drastically. (shrink)

In 2001, Le Bars proved that there exists an existential monadic second-order sentence such that the probability that it is true on [Formula: see text] does not converge and conjectured that, for EMSO sentences with two first-order variables, the zero–one law holds. In this paper, we prove that the conjecture fails for [Formula: see text], and give new examples of sentences with fewer variables without convergence.

We show that the analysis of Keisler’s order can be localized to the study of φ-types. Specifically, if is a regular ultrafilter on λ such that and M is a model whose theory is countable, then is λ+-saturated iff it realizes all φ-types of size λ.

In this paper, logics are conceived as two-sorted first-order structures, and we argue that this broad definition encompasses a wide class of logics with theoretical interest as well as interest from the point of view of applications. The language, concepts and methods of model theory can thus be used to describe the relationship between logics through morphisms of structures called transfers. This leads to a formal framework for studying several properties of abstract logics and their attributes such as consequence operator, (...) syntactical structure, and internal transformations. In particular, we treat Belief Revision Systems (BRS) as our main example, defining the Wide Belief Revision Systems (WBRS''s). This generalization allows us to define BRS''s in an abstract setting for classical and non-standard logics. We also show how the concept of translation between logics can be obtained as a particular case of transfers. (shrink)

Some theorists, worried about liberalism’s potential as a foundation for public health ethics, suggest that republicanism provides a better background of justification for public health policies, interventions, etc. In this article, this suggestion is put to the test, and it is argued that (i) contemporary (civic) republicanism and liberalism are not nearly as opposed as it is sometimes suggested, and that (ii) the kind of republicanism which one leading scholar in the field, Bruce Jennings, as an alternative to liberalism, does (...) not reflect the contemporary understanding of republicanism as held by, e.g. Phillip Pettit et al. (shrink)

Let T 1 , T 2 be countable first-order theories, M i ⊨ T i , and ������ any regular ultrafilter on λ ≥ $\aleph_{0}$ . A longstanding open problem of Keisler asks when T 2 is more complex than T 1 , as measured by the fact that for any such λ, ������, if the ultrapower (M 2 ) λ /������ realizes all types over sets of size ≤ λ, then so must the ultrapower (M 1 ) λ /������. (...) In this paper, building on the author's prior work [12] [13] [14], we show that the relative complexity of first-order theories in Keisler's sense is reflected in the relative graph-theoretic complexity of sequences of hypergraphs associated to formulas of the theory. After reviewing prior work on Keisler's order, we present the new construction in the context of ultrapowers, give various applications to the open question of the unstable classification, and investigate the interaction between theories and regularizing sets. We show that there is a minimum unstable theory, a minimum TP 2 theory, and that maximality is implied by the density of certain graph edges (between components arising from Szemerédi-regular decompositions) remaining bounded away from 0, 1. We also introduce and discuss flexible ultrafilters, a relevant class of regular ultrafilters which reflect the sensitivity of certain unstable (non low) theories to the sizes of regularizing sets, and prove that any ultrafilter which saturates the minimal TP 2 theory is flexible. (shrink)

This article develops an account of the nature and limits of the state’s legislative authority that closely attends to the challenge of harmonizing Kant’s ethical and juridical theories. It clarifies some key Kantian concepts and terms, then explains the way in which the state’s three interlocking authorities – legislative, executive, and judicial – are metaphysically distinct and mutually dependent. It describes the emergence of the Kantian state and identifies the preconditions of its authority. Then it offers a metaphysical model of (...) the Kantian state and uses it to argue that the activity of juridical lawgiving is an act of the omnilateral will itself. Legislative authority is limited in the sense that it does not include the capacity to create juridical laws that are conceptually incompatible with the idea of universal external freedom. I argue that my proposed account of the legislative authority is wholly consistent with that authority’s exclusive lawgiving capacity and does not threaten the possibility of ‘distributive justice’ – the legal finality that is the sine qua non of a civil condition. (shrink)